Plans to save £4.8 billion by 2030 were tabled by the government's secretary of state for work and pensions.
The proposals included the tightening of criteria for personal independence payments (PIP), a welfare benefit designed to help those of working age cover their costs of living.
But the original cuts caused a large-scale rebellion among the governing Labour Party. Some 126 Labour MPs had previously signed a "reasoned amendment" to the bill, proposed by treasure committee chairwoman Dame Meg Hillier.
Causing division among the country's largest political party, one of the leading rebels has been York Central MP Rachael Maskell - who put forward a second amendment rejecting the bill, with the backing of 138 disability groups.
Her amendment has been signed by 39 Labour MPs.
In an attempt to soften the rebellion, the Government last week reduced the impact of its changes to protect some 370,000 existing PIP claimants who had been set to lose out following reassessment.
The House of Commons is expected to vote on the bill at around 7pm today (July 1).
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