The Premier Inn will be opening in Layerthorpe following the completion of the scheme by CBR Investment Management.
Premier Inn has signed a lease agreement for 25 years on the building, located on Foss Islands Road.
Leeds-based Clegg Construction was the main contractor.
The hotel is four-storeys and was built on a one-acre plot that previously contained a retail warehouse leased by Carpetright.
This will be the sixth Premier Inn in York and when approved by City of York Council in 2021, it promised to create 55 jobs.
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